Tetramethylenedisulfotetramine (TMDT) is a highly lethal neuroactive rodenticide responsible for many accidental and intentional poisonings in mainland China. 2006 Feb;12(1):87. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have primarily utilized parenteral routes. Tetramethylenedisulfotetramine (tetramine, or TETS) is a highly potent convulsant commonly used as a black market rodenticide in Asia and is one of the most dangerous food and water contaminants that could be used in an intentional poisoning scenario [].TETS is easily synthesized [], tasteless, odorless, remarkably stable [], environmentally persistent [], and particularly . Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. Although banned, it has been responsible for thousands of accidental, intentional, and mass poisonings in mainland China and elsewhere. tetramethylenedisulfotetramine Pyridoxine . Antidotes for tetramine poisoning Hong Kong Med J. When crystallized from acetone, it forms cubic . Tetramethylenedisulfotetramine (TETS) is a feared chemical threat agent because of its high convulsant toxicity, ease of synthesis, and availability even though it is banned as a rodenticide. externally and internally decontaminated as appropriate, with. Due to its high level of toxicity for. We have previously developed a realistic model of voluntary TETS consumption, in which rats promptly consumed a piece of cereal containing a dose of TETS that led to rapid progression of toxic signs . Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Tetramethylenedisulfotetramine (TETS) is a rodenticide which was banned worldwide in the early 1990s (Whitlow et al., 2005). Tetramethylenedisulfotetramine (TETS) is a feared chemical threat agent because of its high convulsant toxicity, ease of synthesis, and availability even though it is banned as a rodenticide. Human clinical cases of TMDT poisoning have reported similar paroxysmal high amplitude unilateral and bilateral ictal activity with generalized spike and slow wave discharges (Chau et al . Tetramethylenedisulfotetramine (TETS) is an organic compound that is used as a rodenticide (rat poison). (4) The cumulative doses of diazepam and Phenobarbital, and the . Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have . Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. Due to its high level of toxicity for humans, the use of TETS as a rodenticide . Lethal dose for humans is considered to be 7-10 milligrams. Earlier physiological evidence indicating action as a GABA receptor an-tagonist and inhibitor of [35S]TBPS and [3H]EBOB binding is con- However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. 11 In Sep- tetramethylenedisulfotetramine poisoning and the lack of other. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Ease of synthesis, water solubility, potency, and difficulty to treat make TMDT a potential weapon for terrorist activity. Its chief application is. Although clinical reports clearly show that poisoning via food and drink is the main rout However, several accidental and intentional poisonings have been reported since the ban, predominantly in China (Cao et al., 2012a), but also in the United States (Barrueto et al., 2003). Earlier physiological evidence indicating action as a GABA receptor antagonist and inhibitor of [ 35 S]TBPS and [ 3 H]EBOB binding is . However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. . Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. We have previously developed a realistic model of voluntary TETS consumption, in which rats promptly consumed a piece of cereal containing a dose of TETS that led to rapid progression of toxic signs . Tetramine is prohibited in the United States and banned in China, but it is still widely accessible. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. 1. Tetramethylenedisulfotetramine (TETS) is a highly toxic and potent convulsant compound that in the past has been used as a rodenticide, mainly in Asia. Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. Publication types Letter Comment . Symptoms of TETS poisoning include nausea, arrhythmias, tremor, convulsions, respiratory failure . It can be synthesized by reacting sulfamide with formaldehyde under acidic condition. . It is a sulfamide derivative. China.10 In July 1991, a mass poisoning occurred in Heibei Province, China, where 78 people were purposely poisoned with tetramethylenedisulfotetramine-contaminated rice. Tetramethylenedisulfotetramine (tetramine, TETS, TMDT) is a seizure-producing neurotoxic chemical formed by the condensation of sulfamide and formaldehyde. Poisoning is diagnosed by gas chromatography and the treatment is mainly supportive, with large doses of . (3) The serum levels of beta-EP, ET, NO and TNF in 3 non-survivors were very high at hospitalization and continued to increase in the course of treatment. Tetramine is rapid acting with signs and symptoms appearing as quickly as 1-5 minutes depending on the dose. reasonable explanations for the illness. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. It is an odorless, tasteless white powder that is slightly soluble in water, DMSO and acetone, and insoluble in methanol and ethanol.It is a sulfamide derivative. The toxicologic properties of the seizureinducing rodenticide tetramethylenedisulfotetramine, more recent advances in understanding of its properties, and recommendations . Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Poisoning by an Illegally Imported Chinese Rodenticide Containing Tetramethylenedisulfotetramine --- New York City, 2002 Illegally imported foreign products can result in domestic exposures to unusual toxic chemicals, and health-care providers might not be able to provide appropriate therapy because the chemical ingredients might not be listed or recognized even after translation of the . The report of this investigation highlights the need to prevent such poisonings through increased public education, awareness, and enforcement of laws banning the . Its chemical formula is C 4 H 8 N 4 O 4 S 2 and its chemical name is 2,6-dithia-1,3,5,7-tetraazatricyclo(3.3.1.1(3,7)-decane 2,2,6,6-tetraoxide). PMID: 16495600 No abstract available. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Tetramethylenedisulfotetramine Tetramethylenedisulfotetramine (TETS, DSTA, also called tetramine) is a toxic organic chemical. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. It is an odorless, tasteless white powder. Poisoning by an Illegally Imported Chinese Rodenticide Containing Tetramethylenedisulfotetramine --- New York City, 2002 Illegally imported foreign products can result in domestic exposures to unusual toxic chemicals, and health-care providers might not be able to provide appropriate therapy because the chemical ingredients might not be listed or recognized even after translation of the . Ingestion of the noncompetitive GABA A receptor antagonist tetramethylenedisulfotetramine (TETS) results in arrhythmias, respiratory depression, and life-threatening convulsive status epilepticus. Tetramethylenedisulfotetramine (TETS) is an organic compound used as a rodenticide (rat poison). It is uncommon and therefore little known. TNF levels returned to normal range on days 9, 11 and 17 after poisoning respectively in the mild, moderate and severe groups. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Due to its high level of toxicity for humans, the use of TETS as a rodenticide has been banned and its production has been discontinued. Patients should be. Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. My watch list . An optimal regimen for treatment of poisoning has not been established. 2012), occluding the chloride channel and acting as a potent antagonist (Zhao et al., 2014). This report describes the first known case in the United States of exposure to a Chinese rodenticide containing the toxin tetramethylenedisulfotetramine (TETS), a convulsant poison. . Tetramethylenedisulfotetramine (TETS, DSTA, also called tetramine) is a toxic organic chemical.Its chief application is as a rodenticide (rat poison). One week after poisoning, both patients underwent one session of high-volume haemofiltration followed by charcoal haemoperfusion to eliminate the toxin from the body. However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. Recently, a governmentally banned rodenticide from China, tetramethylenedisulfotetramine, was reported responsible for human poisoning in the United States. Authors C K Chan, Y C Chan. 3 Tetramethylenedisulfotetramine is a lethal, neurotoxic rodenticide that has been the source of numerous intentional and unintentional poisonings in China.4, 5, 6 This review describes the . Tetramethylenedisulfotetramine, commonly known as tetramine, is a colorless, odorless, and extremely toxic rodenticide. Tetramethylenedisulfotetramine (tetramine, or TETS) is a highly toxic rodenticide that has been responsible for over 14,000 accidental and intentional poisonings worldwide. Significance. Tetramethylenedisulfotetramine (TETS, tetramine) is a toxic organic compound that is used as an effective rodenticide. We characterized TMDT-induced convulsions and mortality in male . Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Introduction. Tetramethylenedisulfotetramine (TETS) is a highly toxic convulsant and a potent antagonist of However, this neurotoxin is not only toxic to rodents, it also causes poisoning in humans. [2] It is an odorless, tasteless white powder that is slightly soluble in water, DMSO and acetone, and insoluble in methanol and ethanol. Ingestion of the noncompetitive GABA A receptor antagonist tetramethylenedisulfotetramine (TETS) results in arrhythmias, respiratory depression, and life-threatening convulsive status epilepticus. The seizure-inducing rodenticide tetramethylenedisulfotetramine is one of the most toxic of these agents. Given the recent case report that confirms the presence of tetramethylenedisulfotetramine in the United States, the toxicity of the compound, its unique physical properties, the absence of an antidote, and the history of its use as an agent of intentional mass poisoning, public health entities have undertaken educational efforts to inform the . poisoning in humans.

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